
Biophysics research advancing the frontier of knowledge
Ion Channel Regulation
We use simultaneous total internal reflection fluorescence (TIRF) microscopy and electrophysiology to interrogate the functional regulation of ion channels in response to inflammatory mediators.
Protein Energetics & Dynamics
We develop novel fluorescence spectroscopy methods to measure the energetics of conformational rearrangements in proteins. Interrogating the mechanisms of allostery using noncanonical amino acids, transition metal fluorescence resonance energy transfer, and time-resolved fluorescence lifetime analysis opens new frontiers of understanding.